过去一年中添加的文章,按日期排序

An improved epigenetic counter to track mitotic age in normal and precancerous tissues

T Zhu, H Tong, Z Du, S Beck… - Nature Communications, 2024 - nature.com
5 天前 - … and preventive oncology is to develop novel strategies for … age, somatic mutations
and DNA methylation (DNAm) have … the cumulative number of DNA methylation errors arising …

Histone ubiquitination: Role in genome integrity and chromatin organization

NB Ghate, KS Nadkarni, GK Barik, SS Tat… - … et Biophysica Acta (BBA …, 2024 - Elsevier
5 天前 - … proteins in various cellular and developmental processes, ubiquitination of the
histones … Thus, depletion of FBXL10 results in dense de novo DNA methylation of the promoters …

Microbial Synthetic Epigenetic Tools Design and Applications

I Komera, X Chen, L Liu, C Gao - ACS Synthetic Biology, 2024 - ACS Publications
5 天前 - … In this review, we explore advancements in developing … in the development of
synthetic epigenetic tools. … activity achieving controllable DNA methylation and gene expression …

Genome-wide epigenetic signatures facilitated the variant classification of PURA gene and uncovered the pathomechanism of PURA-related neurodevelopmental …

B Xiao, W Dai, Y Zhan, W Qiu, H Zhang, DP Liu… - Genetics in …, 2024 - Elsevier
5 天前 - … neonatal abnormalities and developmental delay. Using genome-wide DNA
methylation analysis on patients with PURA variants, we aim to 31 establish PURA-NDD-specific …

The Molecular Basis of the Augmented Cardiovascular Risk in Offspring of Mothers with Hypertensive Disorders of Pregnancy

A Svigkou, V Katsi, VG Kordalis, K Tsioufis - International Journal of …, 2024 - mdpi.com
5 天前 - … Moreover, the potential role of epigenetic factors, such as DNA methylation and …
affect the development of the cardiovascular and renal systems. DNA methylation and histone …

Exploring novel insights into the molecular mechanisms underlying Bisphenol A-induced toxicity: A persistent threat to human health

I Ahmad, M Kaur, D Tyagi, TB Singh, G Kaur… - Environmental …, 2024 - Elsevier
6 天前 - … , DNA repair, and other defense mechanisms, due to which the growth and development
of a fetus including sexual development… changes such as DNA methylation and histone …

DNA methylation plays important roles in lifestyle transition of Arthrobotrys oligospora

J Shi, J Liu, H Li, Y Tang, S Liu, Z Sun… - IET Systems …, 2024 - Wiley Online Library
6 天前 - … Here, the DNA methylation profile was explored during trap induction of Arthrobotrys
oligospora, a typical NTF that captures nematodes by developing adhesive networks. …

[HTML][HTML] Methods in DNA methylation array dataset analysis: A Review

K Sahoo, V Sundararajan - Computational and Structural Biotechnology …, 2024 - Elsevier
6 天前 - development and … DNA methylation is a crucial epigenetic modification of the
genome important for cellular reprogramming, tissue differentiation, and proper development

[引用][C] Next-Generation Molecular Residual Disease Assays: Do We Have the Tools to Evaluate Them Properly?

D Stetson, P Labrousse, H Russell, D Shera… - Journal of Clinical …, 2024 - ascopubs.org
6 天前 - … 8-10 Much of the research and/or clinical development focus has been on ctDNA …
somatic variants, such as indication-specific DNA methylation signatures, 15-18 fragment size …

PROMINENT: AN INTERPRETABLE DEEP LEARNING METHOD TO PREDICT PHENOTYPES USING DNA METHYLATION

L Zhang - 2024 - d-scholarship.pitt.edu
6 天前 - DNA methylation (DNAm) is an epigenetic mark that regulates genome … development
in mammals. To understand the complex interplay between genetics, DNA methylation, …