DNA methylation in development and human disease

S Gopalakrishnan, BO Van Emburgh… - … Molecular Mechanisms of …, 2008 - Elsevier
DNA methylation is a heritable and stable epigenetic mark associated with transcriptional
repression. Changes in the patterns and levels of global and regional DNA methylation
regulate development and contribute directly to disease states such as cancer. Recent
findings provide intriguing insights into the epigenetic crosstalk between DNA methylation,
histone modifications, and small interfering RNAs in the control of cell development and
carcinogenesis. In this review, we summarize the recent studies in DNA methylation …
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