… drives can be seeded at very low numbers to do so. This Review focuses on the latter low-threshold
gene drives … optimized second-generation drives have been developed over the past …

… gene drive system involves a TARE drive carrying Cas9 together with two homing drives, one
… still sufficient to support effective population modification based on previous modeling [40]. …

… elements sit at a fixed chromosomal position and include a DNA sequence-modifying
enzyme such as Cas9/gRNAs that disrupts endogenous versions of an essential …

… DNA sequencing of the target site in F1 and F2 mosquitoes with exceptional phenotypes …
Our work investigates the ability of AgNosCd-1, a population modification-based drive system …

… A conceptually important additional method for limiting suppression to a target island, that
applies to all DNA sequence modification-based drives, focuses on targeting what are known …

… and PAX5 genes will likely help to identify a significant proportion of cases with impending
relapse, although this strategy might require dynamic modification based on prospective data …

… PAM recognition, leading to complete loss of DNA binding by Csy–crRNA 68 (Fig. 1f). This
post-translational protein modification-based mechanism could make AcrIF11 a more potent …

… Wolbachia is not the only choice for driving genes into vector populations (12, 28), but this …
sequences were aligned by using a cluster algorithm followed by manual modification based …

… DNA-binding domains overlap (Stoddard 2011). When an amino acid sequence is altered to
achieve new DNA sequence … to conduct targeted genome modification based on their needs…

… carry genes for CRISPR–Cas adaptive immune systems 1 , which provide immunological
memory by inserting short DNA sequences from phage and other parasitic DNA elements into …