DNAH11 localization in the proximal region of respiratory cilia defines distinct outer dynein arm complexes
GW Dougherty, NT Loges, JA Klinkenbusch… - American journal of …, 2016 - atsjournals.org
Primary ciliary dyskinesia (PCD) is a recessively inherited disease that leads to chronic
respiratory disorders owing to impaired mucociliary clearance. Conventional transmission
electron microscopy (TEM) is a diagnostic standard to identify ultrastructural defects in
respiratory cilia but is not useful in approximately 30% of PCD cases, which have normal
ciliary ultrastructure. DNAH11 mutations are a common cause of PCD with normal ciliary
ultrastructure and hyperkinetic ciliary beating, but its pathophysiology remains poorly …
respiratory disorders owing to impaired mucociliary clearance. Conventional transmission
electron microscopy (TEM) is a diagnostic standard to identify ultrastructural defects in
respiratory cilia but is not useful in approximately 30% of PCD cases, which have normal
ciliary ultrastructure. DNAH11 mutations are a common cause of PCD with normal ciliary
ultrastructure and hyperkinetic ciliary beating, but its pathophysiology remains poorly …
DNAH11 Localization in the Proximal Region of Respiratory Cilia Defines Distinct Outer Dynein Arm Complexes
MA Kashef MD - 2016 - scholarlycommons.libraryinfo.bhs …
Primary ciliary dyskinesia (PCD) is a recessively inherited disease that leads to chronic
respiratory disorders owing to impaired mucociliary clearance. Conventional transmission
electron microscopy (TEM) is a diagnostic standard to identify ultrastructural defects in
respiratory cilia but is not useful in approximately 30% of PCD cases, which have normal
ciliary ultrastructure. DNAH11 mutations are a common cause of PCD with normal ciliary
ultrastructure and hyperkinetic ciliary beating, but its pathophysiology remains poorly …
respiratory disorders owing to impaired mucociliary clearance. Conventional transmission
electron microscopy (TEM) is a diagnostic standard to identify ultrastructural defects in
respiratory cilia but is not useful in approximately 30% of PCD cases, which have normal
ciliary ultrastructure. DNAH11 mutations are a common cause of PCD with normal ciliary
ultrastructure and hyperkinetic ciliary beating, but its pathophysiology remains poorly …
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