Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, is a lifethreatening drug reaction usually caused by aromatic anticonvulsants, and manifests itself by skin rash, fever, hematological abnormalities sometimes accompanied by internal organ involvement such as hepatitis and nephritis. Although cases of toxic epidermal necrolysis (TEN) have been reported due to ciprofloxacin use, the development of DRESS is very scarce in the literature. Herein a 20-year-old female patient who developed DRESS with TEN and internal organ involvement after using oral ciprofloxacin for her complaints of nasal discharge, diarrhea and vomiting is presented. She was treated successfully with the hyperbaric oxygen and intravenous immunoglobulin administration.