Daidzein stimulates osteogenesis facilitating proliferation, differentiation, and antiapoptosis in human osteoblast-like MG-63 cells via estrogen receptor–dependent …
X Jin, J Sun, B Yu, Y Wang, WJ Sun, J Yang… - Nutrition Research, 2017 - Elsevier
Daidzein, a natural soy isoflavone, has a structure similar to estradiol and exhibiting bone-
sparing effects against osteoporosis. However, the molecular mechanisms of osteogenesis
remain unclear. We hypothesized that daidzein stimulates osteogenesis through estrogen
receptor (ER)–dependent signal pathways. To test this hypothesis, we investigated the
effects of daidzein compared with 17β-estradiol on proliferation, differentiation, and cisplatin-
induced apoptosis in human osteoblast-like MG-63 cells containing 2 ER isoforms. The …
sparing effects against osteoporosis. However, the molecular mechanisms of osteogenesis
remain unclear. We hypothesized that daidzein stimulates osteogenesis through estrogen
receptor (ER)–dependent signal pathways. To test this hypothesis, we investigated the
effects of daidzein compared with 17β-estradiol on proliferation, differentiation, and cisplatin-
induced apoptosis in human osteoblast-like MG-63 cells containing 2 ER isoforms. The …
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