The aim of the present study was to design novel antidiabetic agents by exploring one of various targets. Here we have chosen DPP, ie Dipeptidyl peptidase. Considering the earlier approach opted by various researchers, we have virtually designed a series of naphthyridine analogues (1a-j) considering naphthyridine ring as a privileged scaffold. Prior synthesizing those molecules, we have carried out molecular docking study using AUTODOCK 4, in order to establish, whether they are capable of making any kind of interaction with the active site of target receptor, which we have taken 3NOX (dipeptidyl peptidase).