Deciphering the splicing code

Y Barash, JA Calarco, W Gao, Q Pan, X Wang, O Shai… - Nature, 2010 - nature.com
… Here we describe the assembly of a ‘splicing code’, which uses combinations of hundreds
… in alternative splicing for thousands of exons. The code determines new classes of splicing

The splicing code

M Baralle, FE Baralle - Biosystems, 2018 - Elsevier
… towards the deciphering of the splicing code has been … in play whose code we are really only
beginning to decipher and … identity acquisition through alternative splicing. Among these for …

Deciphering the plant splicing code: experimental and computational approaches for predicting alternative splicing and splicing regulatory elements

ASN Reddy, MF Rogers, DN Richardson… - Frontiers in plant …, 2012 - frontiersin.org
… Here, we review the current state of research on splicing regulatory elements (SREs) and …
features involved in AS regulation and contribute to deciphering the splicing code in plants. …

The human splicing code reveals new insights into the genetic determinants of disease

HY Xiong, B Alipanahi, LJ Lee, H Bretschneider… - Science, 2015 - science.org
… Then we correlated the RBP binding affinities with the residual splicing activity not captured
by the code, which was obtained by subtracting the code predictions from the observed …

Splicing in disease: disruption of the splicing code and the decoding machinery

GS Wang, TA Cooper - Nature Reviews Genetics, 2007 - nature.com
… up a splicing code that is required for efficient pre-mRNA splicing. A … splicing rather than the
predicted amino-acid change. … A long-term goal of deciphering the splicing code is to acquire …

Deciphering RNA splicing logic with interpretable machine learning

SE Liao, M Sudarshan… - Proceedings of the …, 2023 - National Acad Sciences
… Beyond the context of splicing, the interpretable-by-design framework can be used to
decipher the multiple, complex, and overlapping codes that dictate biomolecular processing. …

Deciphering the impact of coding and non-coding SCN1A gene variants on RNA splicing

P Sparber, M Sharova, K Davydenko, D Pyankov… - Brain, 2024 - academic.oup.com
splicing and conclude that splicing variants are substantially misannotated and under-represented.
We created a splicing reporter system consisting of 18 splicing … -type splicing pattern …

Machine learning for discovery: deciphering RNA splicing logic

SE Liao, M Sudarshan, O Regev - bioRxiv, 2022 - biorxiv.org
… Beyond the context of splicing, the interpretable-by-design framework can be used to
decipher the multiple, complex, and overlapping codes that dictate biomolecular processing. …

From computational models of the splicing code to regulatory mechanisms and therapeutic implications

C Capitanchik, OG Wilkins, N Wagner… - Nature Reviews …, 2024 - nature.com
… The potential to solve the splicing regulatory code by combining modelling and … models of
the splicing code create new opportunities for studies of splicing mechanisms and therapeutics…

Understanding alternative splicing: towards a cellular code

AJ Matlin, F Clark, CWJ Smith - Nature reviews Molecular cell biology, 2005 - nature.com
… recent introduction of alternative splicing microarrays, which allow parallel analysis of large
numbers of alternative splicing events and should facilitate the deciphering of cellular codes. …