Deciphering the splicing code
… Here we describe the assembly of a ‘splicing code’, which uses combinations of hundreds
… in alternative splicing for thousands of exons. The code determines new classes of splicing …
… in alternative splicing for thousands of exons. The code determines new classes of splicing …
The splicing code
M Baralle, FE Baralle - Biosystems, 2018 - Elsevier
… towards the deciphering of the splicing code has been … in play whose code we are really only
beginning to decipher and … identity acquisition through alternative splicing. Among these for …
beginning to decipher and … identity acquisition through alternative splicing. Among these for …
Deciphering the plant splicing code: experimental and computational approaches for predicting alternative splicing and splicing regulatory elements
… Here, we review the current state of research on splicing regulatory elements (SREs) and …
features involved in AS regulation and contribute to deciphering the splicing code in plants. …
features involved in AS regulation and contribute to deciphering the splicing code in plants. …
The human splicing code reveals new insights into the genetic determinants of disease
… Then we correlated the RBP binding affinities with the residual splicing activity not captured
by the code, which was obtained by subtracting the code predictions from the observed …
by the code, which was obtained by subtracting the code predictions from the observed …
Splicing in disease: disruption of the splicing code and the decoding machinery
… up a splicing code that is required for efficient pre-mRNA splicing. A … splicing rather than the
predicted amino-acid change. … A long-term goal of deciphering the splicing code is to acquire …
predicted amino-acid change. … A long-term goal of deciphering the splicing code is to acquire …
Deciphering RNA splicing logic with interpretable machine learning
SE Liao, M Sudarshan… - Proceedings of the …, 2023 - National Acad Sciences
… Beyond the context of splicing, the interpretable-by-design framework can be used to
decipher the multiple, complex, and overlapping codes that dictate biomolecular processing. …
decipher the multiple, complex, and overlapping codes that dictate biomolecular processing. …
Deciphering the impact of coding and non-coding SCN1A gene variants on RNA splicing
… splicing and conclude that splicing variants are substantially misannotated and under-represented.
We created a splicing reporter system consisting of 18 splicing … -type splicing pattern …
We created a splicing reporter system consisting of 18 splicing … -type splicing pattern …
Machine learning for discovery: deciphering RNA splicing logic
SE Liao, M Sudarshan, O Regev - bioRxiv, 2022 - biorxiv.org
… Beyond the context of splicing, the interpretable-by-design framework can be used to
decipher the multiple, complex, and overlapping codes that dictate biomolecular processing. …
decipher the multiple, complex, and overlapping codes that dictate biomolecular processing. …
From computational models of the splicing code to regulatory mechanisms and therapeutic implications
C Capitanchik, OG Wilkins, N Wagner… - Nature Reviews …, 2024 - nature.com
… The potential to solve the splicing regulatory code by combining modelling and … models of
the splicing code create new opportunities for studies of splicing mechanisms and therapeutics…
the splicing code create new opportunities for studies of splicing mechanisms and therapeutics…
Understanding alternative splicing: towards a cellular code
AJ Matlin, F Clark, CWJ Smith - Nature reviews Molecular cell biology, 2005 - nature.com
… recent introduction of alternative splicing microarrays, which allow parallel analysis of large
numbers of alternative splicing events and should facilitate the deciphering of cellular codes. …
numbers of alternative splicing events and should facilitate the deciphering of cellular codes. …