Deconstructing and reconstructing the mouse and human early embryo

MN Shahbazi, M Zernicka-Goetz - Nature cell biology, 2018 - nature.com
Nature cell biology, 2018nature.com
The emergence of form and function during mammalian embryogenesis is a complex
process that involves multiple regulatory levels. The foundations of the body plan are laid
throughout the first days of post-implantation development as embryonic stem cells undergo
symmetry breaking and initiate lineage specification, in a process that coincides with a
global morphological reorganization of the embryo. Here, we review experimental models
and how they have shaped our current understanding of the post-implantation mammalian …
Abstract
The emergence of form and function during mammalian embryogenesis is a complex process that involves multiple regulatory levels. The foundations of the body plan are laid throughout the first days of post-implantation development as embryonic stem cells undergo symmetry breaking and initiate lineage specification, in a process that coincides with a global morphological reorganization of the embryo. Here, we review experimental models and how they have shaped our current understanding of the post-implantation mammalian embryo.
nature.com
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