Decreased core crystallinity facilitated drug loading in polymeric micelles without affecting their biological performances
J Gou, S Feng, H Xu, G Fang, Y Chao, Y Zhang… - …, 2015 - ACS Publications
Cargo-loading capacity of polymeric micelles could be improved by reducing the core
crystallinity and the improvement in the amount of loaded cargo was cargo-polymer affinity
dependent. The effect of medium chain triglyceride (MCT) in inhibiting PCL crystallization
was confirmed by DSC and polarized microscope. When incorporating MCT into polymeric
micelles, the maximum drug loading of disulfiram (DSF), cabazitaxel (CTX), and TM-2 (a
taxane derivative) increased from 2.61±0.100%, 13.5±0.316%, and 20.9±1.57% to …
crystallinity and the improvement in the amount of loaded cargo was cargo-polymer affinity
dependent. The effect of medium chain triglyceride (MCT) in inhibiting PCL crystallization
was confirmed by DSC and polarized microscope. When incorporating MCT into polymeric
micelles, the maximum drug loading of disulfiram (DSF), cabazitaxel (CTX), and TM-2 (a
taxane derivative) increased from 2.61±0.100%, 13.5±0.316%, and 20.9±1.57% to …
[引用][C] Decreased Core Crystallinity Facilitated Drug Loading in Polymeric Micelles without Affecting Their Biological Performances
G Jingxin, F Shuangshuang, X Helin, F Guihua… - 2015
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