[HTML][HTML] Decreased inflammatory response in Toll-like receptor 2 knockout mice is associated with exacerbated Pneumocystis pneumonia
SH Wang, C Zhang, ME Lasbury, CP Liao… - Microbes and …, 2008 - Elsevier
Pneumocystis pneumonia (PcP) is marked by substantial inflammatory damage to the lung.
We have found that Toll-like receptor 2 (TLR2) mediates macrophage inflammatory
responses to Pneumocystis and hypothesized that TLR2 deficiency would lead to less
severe inflammation and milder lung injury during PcP. Histopathology examination showed
that TLR2−/− mice with PcP indeed exhibited milder pulmonary inflammation. TLR2−/−
mouse lungs contained less TNF-α and displayed lower levels of NF-κB activation during …
We have found that Toll-like receptor 2 (TLR2) mediates macrophage inflammatory
responses to Pneumocystis and hypothesized that TLR2 deficiency would lead to less
severe inflammation and milder lung injury during PcP. Histopathology examination showed
that TLR2−/− mice with PcP indeed exhibited milder pulmonary inflammation. TLR2−/−
mouse lungs contained less TNF-α and displayed lower levels of NF-κB activation during …
Decreased inflammatory response in Toll-like receptor 2 knockout mice is associated with exacerbated Pneumocystis pneumonia.
WSH Wang ShaoHung, C Zhang, ME Lasbury, CP Liao… - 2008 - cabidigitallibrary.org
Pneumocystis pneumonia (PcP) is marked by substantial inflammatory damage to the lung.
We have found that Toll-like receptor 2 (TLR2) mediates macrophage inflammatory
responses to Pneumocystis and hypothesized that TLR2 deficiency would lead to less
severe inflammation and milder lung injury during PcP. Histopathology examination showed
that TLR2-/-mice with PcP indeed exhibited milder pulmonary inflammation. TLR2-/-mouse
lungs contained less TNF-α and displayed lower levels of NF-κB activation during PcP …
We have found that Toll-like receptor 2 (TLR2) mediates macrophage inflammatory
responses to Pneumocystis and hypothesized that TLR2 deficiency would lead to less
severe inflammation and milder lung injury during PcP. Histopathology examination showed
that TLR2-/-mice with PcP indeed exhibited milder pulmonary inflammation. TLR2-/-mouse
lungs contained less TNF-α and displayed lower levels of NF-κB activation during PcP …
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