DeepIPs: comprehensive assessment and computational identification of phosphorylation sites of SARS-CoV-2 infection using a deep learning-based approach
Briefings in Bioinformatics, 2021•academic.oup.com
The rapid spread of SARS-CoV-2 infection around the globe has caused a massive health
and socioeconomic crisis. Identification of phosphorylation sites is an important step for
understanding the molecular mechanisms of SARS-CoV-2 infection and the changes within
the host cells pathways. In this study, we present DeepIPs, a first specific deep-learning
architecture to identify phosphorylation sites in host cells infected with SARS-CoV-2.
DeepIPs consists of the most popular word embedding method and convolutional neural …
and socioeconomic crisis. Identification of phosphorylation sites is an important step for
understanding the molecular mechanisms of SARS-CoV-2 infection and the changes within
the host cells pathways. In this study, we present DeepIPs, a first specific deep-learning
architecture to identify phosphorylation sites in host cells infected with SARS-CoV-2.
DeepIPs consists of the most popular word embedding method and convolutional neural …
Abstract
The rapid spread of SARS-CoV-2 infection around the globe has caused a massive health and socioeconomic crisis. Identification of phosphorylation sites is an important step for understanding the molecular mechanisms of SARS-CoV-2 infection and the changes within the host cells pathways. In this study, we present DeepIPs, a first specific deep-learning architecture to identify phosphorylation sites in host cells infected with SARS-CoV-2. DeepIPs consists of the most popular word embedding method and convolutional neural network-long short-term memory network architecture to make the final prediction. The independent test demonstrates that DeepIPs improves the prediction performance compared with other existing tools for general phosphorylation sites prediction. Based on the proposed model, a web-server called DeepIPs was established and is freely accessible at http://lin-group.cn/server/DeepIPs. The source code of DeepIPs is freely available at the repository https://github.com/linDing-group/DeepIPs.
Oxford University Press
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