Deletion of BCR region 3′ in chronic myelogenous leukemia
The t (9; 22)(q34; q11) produces the BCR/ABL fusion gene which codifies a 210 kb protein
with a strong tyrosine kinase activity and is involved in cellular development and growth.
Because this translocation is a reciprocal event, it could give rise to a second fusion gene,
ABL-BCR, on the derivative 9q+. We analyzed the influence of the 3′ M-BCR deletion on
the clinical picture at diagnosis and disease outcome in 57 patients with a clinical diagnosis
of CML. Molecular studies were done on DNA from peripheral blood leukocytes or bone …
with a strong tyrosine kinase activity and is involved in cellular development and growth.
Because this translocation is a reciprocal event, it could give rise to a second fusion gene,
ABL-BCR, on the derivative 9q+. We analyzed the influence of the 3′ M-BCR deletion on
the clinical picture at diagnosis and disease outcome in 57 patients with a clinical diagnosis
of CML. Molecular studies were done on DNA from peripheral blood leukocytes or bone …
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