This study involves the use of high-resolution airborne magnetic data to evaluate the thicknesses of sedimentary series in the Bornu Basin, Northeast Nigeria, using three depth approximation techniques (source parameter imaging, standard Euler deconvolution, and 2D GM-SYS forward modelling methods). Three evenly spaced profiles were drawn in the N-S direction on the total magnetic intensity map perpendicular to the regional magnetic structures. These profiles were used to generate three 2-D models. The magnetic signatures were visually assessed to determine the thickness of depo-centres and the position of intrusions. The thicknesses of sedimentary series based on source parameter imaging results are approximately ranged 286 to 615 m, 695 to 1038 m, and 1145 to 5885 m for thin, intermediate, and thick sedimentation, respectively. Similarly, the standard Euler deconvolution result shows thin (130 to 917 m), intermediate (1044 to 1572 m), and thick (1725 to 5974 m) sedimentation. The magnetic model of Profile 1, characterized by two major breaks, shows that the igneous intrusions and basement rocks are covered by sediments with thickness varying from 300 to <3500 m, while Profile 2 has a maximum estimated depth value of about 5000 m at the southern part. Furthermore, the Profile 3 model shows sediment thicknesses of 2500 and 4500 m in the northern and southern flanks of the profile, respectively. The maximum sediment thickness value from the various depth estimation methods used in this study correlate relatively well with each other. Furthermore, the anomalous depth zone revealed by the 2D forward models coincides with the locality of the thick sedimentation revealed by the source parameter imaging and standard Euler-deconvolution (St-ED) methods. The maximum depth values obtained from the various depth estimation methods used in this study correlated strongly with each other. The widespread occurrence of short-wavelength anomalies in the southern part of the study area as indicated by the jagged nature of the magnetic signature was validated by the analytic signal and upward-continuation results. Generally, it was observed that the southern part of the research area is characterized by thick sedimentation and igneous intrusions.