Crouzon and Pfeiffer syndrome are syndromic craniosynostosis caused by specific
mutations in the FGFR genes. Patients share the characteristics of a tall, flattened forehead,
exorbitism, hypertelorism, maxillary hypoplasia and mandibular prognathism. Geometric
morphometrics allows the identification of the global shape changes within and between the
normal and syndromic population. Methods Data from 27 Crouzon-Pfeiffer and 33 normal
subjects were landmarked in order to compare both populations. With principal component …