Design and development of an injectable in situ forming drug delivery system of methotrexate for the treatment of rheumatoid arthritis
MP Venkatesh, S Anis, TMP Kumar - Journal of Drug Delivery Science and …, 2013 - Elsevier
Methotrexate (MTX) is the drug of choice for the treatment of rheumatoid arthritis (RA). At
present there exists a lacuna in delivering methotrexate in suitable dosage form to maintain
optimum plasma concentration to achieve therapeutic efficacy during the treatment period.
Exposure of MTX at higher concentrations resulted in severe side effects. Moreover, the
treatment modality (initial and maintenance dose) of RA is not clinically uniform.
Biodegradable injectable in situ gels offer versatility in delivering drug at predetermined …
present there exists a lacuna in delivering methotrexate in suitable dosage form to maintain
optimum plasma concentration to achieve therapeutic efficacy during the treatment period.
Exposure of MTX at higher concentrations resulted in severe side effects. Moreover, the
treatment modality (initial and maintenance dose) of RA is not clinically uniform.
Biodegradable injectable in situ gels offer versatility in delivering drug at predetermined …
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