Neisseria meningitis remains a leading cause of sepsis and meningitis, and vaccines are
required to prevent infections by this important human pathogen. Factor H binding protein
(fHbp) is a key antigen that elicits protective immunity against the meningococcus and
recruits the host complement regulator, fH. As the high affinity interaction between fHbp and
fH could impair immune responses, we sought to identify non-functional fHbps that could act
as effective immunogens. This was achieved by alanine substitution of fHbps from all three …

Correction: Design and Evaluation of Meningococcal Vaccines through Structure-Based
Modification of Host and Pathogen Molecules - PMC … Correction: Design and Evaluation of
Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen
Molecules … This corrects the article "Design and Evaluation of Meningococcal Vaccines
through Structure-Based Modification of Host and Pathogen Molecules" in volume 8, e1002981. …