[HTML][HTML] Developing a common framework for evaluating the implementation of genomic medicine interventions in clinical care: the IGNITE Network's Common …
Genetics in Medicine, 2018•nature.com
Purpose Implementation research provides a structure for evaluating the clinical integration
of genomic medicine interventions. This paper describes the Implementing Genomics in
Practice (IGNITE) Network's efforts to promote (i) a broader understanding of genomic
medicine implementation research and (ii) the sharing of knowledge generated in the
network. Methods To facilitate this goal, the IGNITE Network Common Measures Working
Group (CMG) members adopted the Consolidated Framework for Implementation Research …
of genomic medicine interventions. This paper describes the Implementing Genomics in
Practice (IGNITE) Network's efforts to promote (i) a broader understanding of genomic
medicine implementation research and (ii) the sharing of knowledge generated in the
network. Methods To facilitate this goal, the IGNITE Network Common Measures Working
Group (CMG) members adopted the Consolidated Framework for Implementation Research …
Abstract
Purpose
Implementation research provides a structure for evaluating the clinical integration of genomic medicine interventions. This paper describes the Implementing Genomics in Practice (IGNITE) Network’s efforts to promote (i) a broader understanding of genomic medicine implementation research and (ii) the sharing of knowledge generated in the network.
Methods
To facilitate this goal, the IGNITE Network Common Measures Working Group (CMG) members adopted the Consolidated Framework for Implementation Research (CFIR) to guide its approach to identifying constructs and measures relevant to evaluating genomic medicine as a whole, standardizing data collection across projects, and combining data in a centralized resource for cross-network analyses.
Results
CMG identified 10 high-priority CFIR constructs as important for genomic medicine. Of those, eight did not have standardized measurement instruments. Therefore, we developed four survey tools to address this gap. In addition, we identified seven high-priority constructs related to patients, families, and communities that did not map to CFIR constructs. Both sets of constructs were combined to create a draft genomic medicine implementation model.
Conclusion
We developed processes to identify constructs deemed valuable for genomic medicine implementation and codified them in a model. These resources are freely available to facilitate knowledge generation and sharing across the field.
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