Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and …

SYK Fong, YC Wong, Z Zuo - Journal of pharmaceutical and biomedical …, 2014 - Elsevier
This study aims to identify and quantify the six major bioactive flavones of the traditional
Chinese medicine Scutellariae Radix (RS), including baicalein, baicalin, wogonin,
wogonoside, oroxylin A and oroxyloside in rat after oral administration of a standardized RS
extract. A novel, sensitive and selective method for simultaneous determination of these six
analytes in rat brain and plasma using solid phase extraction-liquid chromatography–
tandem mass spectrometry (SPE-LC/MS/MS) was developed and fully validated. The lower …

Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and …

YKS Fong YuiKau [Fong, WYC Wong YinCheong… - 2014 - cabidigitallibrary.org
This study aims to identify and quantify the six major bioactive flavones of the traditional
Chinese medicine Scutellariae Radix (RS), including baicalein, baicalin, wogonin,
wogonoside, oroxylin A and oroxyloside in rat after oral administration of a standardized RS
extract. A novel, sensitive and selective method for simultaneous determination of these six
analytes in rat brain and plasma using solid phase extraction-liquid chromatography-tandem
mass spectrometry (SPE-LC/MS/MS) was developed and fully validated. The lower limits of …
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