Development of a polymer stent with shape memory effect as a drug delivery system

HM Wache, DJ Tartakowska, A Hentrich… - Journal of Materials …, 2003 - Springer
HM Wache, DJ Tartakowska, A Hentrich, MH Wagner
Journal of Materials Science: Materials in Medicine, 2003Springer
The article presents a new concept for vascular endoprothesis (stent). Almost all
commercially available stents are made of metallic materials. A common after effect of stent
implantation is restenosis. Several studies on metal stents coated with drug show, that the
use of a drug delivery system may reduce restenosis. The purpose of this work is to develop
a new stent for the drug delivery application. The shape memory properties of thermoplastic
polyurethane allow to design a new fully polymeric self-expandable stent. The possibility to …
Abstract
The article presents a new concept for vascular endoprothesis (stent). Almost all commercially available stents are made of metallic materials. A common after effect of stent implantation is restenosis. Several studies on metal stents coated with drug show, that the use of a drug delivery system may reduce restenosis. The purpose of this work is to develop a new stent for the drug delivery application. The shape memory properties of thermoplastic polyurethane allow to design a new fully polymeric self-expandable stent. The possibility to use the stent as a drug delivery system is described.
Springer
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