Acute infection, often accompanied by fever, is one of the most common reasons for children
to visit a physician. Because of the significant number of children with febrile illnesses
presented to the emergency departments (EDs) or primary care practitioners, the most
important clinical challenge is to identify the patients with serious bacterial infections to
promptly initiate effective antimicrobial treatment. Another challenge is to spare patients with
non-bacterial illnesses from unnecessary treatment with antibiotics. Furthermore …