Differences in bone mineral density between normal‐weight children and children with overweight and obesity: a systematic review and meta‐analysis
J van Leeuwen, BW Koes, WD Paulis… - Obesity …, 2017 - Wiley Online Library
J van Leeuwen, BW Koes, WD Paulis, M van Middelkoop
Obesity Reviews, 2017•Wiley Online LibraryObjective This study examines the differences in bone mineral density between normal‐
weight children and children with overweight or obesity. Methods A systematic review and
meta‐analysis of observational studies (published up to 22 June 2016) on the differences in
bone mineral density between normal‐weight children and overweight and obese children
was performed. Results were pooled when possible and mean differences (MDs) were
calculated between normal‐weight and overweight and normal‐weight and obese children …
weight children and children with overweight or obesity. Methods A systematic review and
meta‐analysis of observational studies (published up to 22 June 2016) on the differences in
bone mineral density between normal‐weight children and overweight and obese children
was performed. Results were pooled when possible and mean differences (MDs) were
calculated between normal‐weight and overweight and normal‐weight and obese children …
Objective
This study examines the differences in bone mineral density between normal‐weight children and children with overweight or obesity.
Methods
A systematic review and meta‐analysis of observational studies (published up to 22 June 2016) on the differences in bone mineral density between normal‐weight children and overweight and obese children was performed. Results were pooled when possible and mean differences (MDs) were calculated between normal‐weight and overweight and normal‐weight and obese children for bone content and density measures at different body sites.
Results
Twenty‐seven studies, with a total of 5,958 children, were included. There was moderate and high quality of evidence that overweight (MD 213 g; 95% confidence interval [CI] 166, 261) and obese children (MD 329 g; 95%CI [229, 430]) have a significantly higher whole body bone mineral content than normal‐weight children. Similar results were found for whole body bone mineral density. Sensitivity analysis showed that the association was stronger in girls.
Conclusions
Overweight and obese children have a significantly higher bone mineral density compared with normal‐weight children. Because there was only one study included with a longitudinal design, the long‐term impact of childhood overweight and obesity on bone health at adulthood is not clear.
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