Differences in the purification and solution properties of PurC gene products from Streptococcus pneumoniae and Bacillus anthracis
(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide synthetase (PurC) is a key
enzyme in the de novo purine biosynthetic pathway of bacteria and an ideal target pathway
for the discovery of antimicrobials. Bacillus anthracis (Ba) and Streptococcus pneumoniae
(Sp) are two of the bacteria shown to be severe detriments to public health. To be able to
carry out the experimentation that leads to drug discovery, high yields of pure soluble
recombinant protein must first be obtained. We studied two recombinant PurC proteins from …
enzyme in the de novo purine biosynthetic pathway of bacteria and an ideal target pathway
for the discovery of antimicrobials. Bacillus anthracis (Ba) and Streptococcus pneumoniae
(Sp) are two of the bacteria shown to be severe detriments to public health. To be able to
carry out the experimentation that leads to drug discovery, high yields of pure soluble
recombinant protein must first be obtained. We studied two recombinant PurC proteins from …
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