Extension of the I-band segment of titin gives rise to part of the diastolic force of cardiac
muscle. Previous studies of human cardiac titin transcripts suggested a series of differential
splicing events in the I-band segment of titin leading to the so-called N2A and N2B isoform
transcripts. Here we investigated titin expression at the protein level in a wide range of
mammalian species. Results indicate that the myocardium coexpresses 2 distinct titin
isoforms: a smaller isoform containing the N2B element only (N2B titin) and a larger isoform …

Extension of the I–band segment of titin gives rise to part of cardiac muscle's diastolic force.
Previous studies of human cardiac titin transcripts suggested a series of differential splicing
events in titins I–band segment leading to the so-called N2A and N2B isoform transcripts.
Here we investigated titin expression at the protein level in a wide range of mammalian
species. Results indicate that the myocardium co-expresses two distinct titin isoforms: a
smaller isoform containing the N2B element only (N2B titin), and a larger isoform with both …