Discovery and refinement of loci associated with lipid levels

Nature genetics, 2013 - nature.com
… at P < 5 × 10 −8 , including 62 loci not previously associated with lipid levels in humans. …
signals in 12 loci. We find that loci associated with blood lipid levels are often associated with …

[HTML][HTML] Discovery and refinement of loci associated with lipid levels

CJ Willer, EM Schmidt, S Sengupta, GM Peloso… - Nature …, 2013 - ncbi.nlm.nih.gov
… To identify new loci and refine known loci influencing these lipids, we … 157 loci associated
with lipid levels at P< 5× 10− 8, including 62 loci not previously associated with lipid levels in …

From lipid locus to drug target through human genomics

SW Van Der Laan, EL Harshfield… - Cardiovascular …, 2018 - academic.oup.com
lipid levels, a number of association studies of major lipidslipids was published in 2010,
which reported the discovery of … resulted in the discovery of eight replicated loci associated with …

Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps

V Iotchkova, J Huang, JA Morris, D Jain, C Barbieri… - Nature …, 2016 - nature.com
… and new loci associated with the 20 traits, we resolve the associations of 59 loci to credible
… 1 Mb of a known locus, one was associated with HDL cholesterol levels (an intronic variant …

Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci

N Zubair, M Graff, J Luis Ambite… - Human molecular …, 2016 - academic.oup.com
… have identified over 150 loci associated with lipid traits, … loci that have low to moderate effects
on lipid levels. Together, these variants explain only 8–10% of the variance in lipid levels, a …

Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci

T Tukiainen, J Kettunen, AJ Kangas… - Human molecular …, 2012 - academic.oup.com
… insights into the biological processes modifying lipid levels. … 95 genetic loci associated with
plasma levels of total cholesterol (… lead SNPs in the lipid loci led to the discovery of additional …

Epigenetic patterns in blood associated with lipid traits predict incident coronary heart disease events and are enriched for results from genome-wide association …

ÅK Hedman, MM Mendelson, RE Marioni… - Circulation …, 2017 - Am Heart Assoc
… CpGs associated with lipid levels in the discovery stage … lipid-associated CpGs were enriched
in lipid and amino acid metabolism processes. A differentially methylated locus associated

Genome-wide approaches to finding novel genes for lipid traits: the start of a long road

AC Edmondson, DJ Rader - Circulation: Cardiovascular Genetics, 2008 - Am Heart Assoc
… disease process affects the lipid profile or when a substantial … in newly discovered
associations with LDL-C and HDL-C. … of new genetic loci associated with lipid phenotypes using …

Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease

G Cadby, C Giles, PE Melton, K Huynh… - Nature …, 2022 - nature.com
… Genes implicated at these loci show functional links between lipid levels and CAD 5 . The
… The majority (69.2%) of the 2137 SNP-lipid associations identified in our discovery GWAS …

Identification and validation of seven new loci showing differential DNA methylation related to serum lipid profile: an epigenome-wide approach. The REGICOR study

S Sayols-Baixeras, I Subirana… - Human molecular …, 2016 - academic.oup.com
… Our aim was to identify loci showing differential DNA methylation related to serum lipid levels.
… 1 intergenic region were new discoveries showing differential methylation related to total …