Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

D Demontis, RK Walters, J Martin, M Mattheisen… - Nature …, 2019 - nature.com
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute
substantially to ADHD susceptibility, but no variants have been robustly associated with
ADHD. We report a genome-wide association meta-analysis of 20,183 individuals
diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide
significance in 12 independent loci, finding important new information about the underlying …

[PDF][PDF] Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

TD Als, E Agerbo, G Baldursson13, R Belliveau… - ub.edu
… Two of the genome-wide significant loci defined by this process in the ADHD meta-analysis
include … In order to refine the genome-wide significant loci, we defined a credible set of
variants in each locus … We applied the Bayesian credible set analysis to each of the 12
genome-wide significant loci
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