… The relevance of the dissociation of circulating pentameric C-reactive protein (pCRP) to its
monomeric … We investigated the role of conformational C-reactive protein changes in vivo. …

… dissociation on activated platelets and H 2 O 2 -treated apoptotic THP-1 and Jurkat T cells,
thereby identifying a mechanism of localized … , and localized platelet-mediated inflammatory …

… Monomeric C-reactive protein is prothrombotic and dissociates from circulating pentameric
C-reactive protein on adhered activated platelets under flow. Cardiovasc Res (2011) 92:328–…

… of the dissociation of circulating pentameric C-reactive protein (pCRP) to its monomeric …
We investigated the role of conformational C-reactive protein changes in vivo. Methods and …

… the causal role of the dissociation mechanism of pCRP and … Pentameric C-reactive protein
is part of the superfamily of … the previously described dissociation and localized deposition of …

… mCRP may then contribute to localizing the inflammatory response. Accumulating evidence
… by dissociation of pentameric CRP to its monomeric subunits. The dissociation occurs on the …

… CRP (mCRP) that has major roles in host defenses and inflammation. Here, we … Dissociation
of pentameric to monomeric C-reactive protein on activated platelets localizes inflammation …

… dissociation, which is in turn reducing localized inflammation and tissue injury. We conclude
that in inflamed tissue, pCRP is dissociated … it aggravates as well as localizes inflammatory …

… pCRP, therefore contribute to localization of inflammation. Of note, … Monomeric C-reactive
protein is prothrombotic and dissociates from circulating pentameric C-reactive protein …

… when subunits are dissociated from the pentamer, and 3.) a transitional isoform where the
… to completion upon dissociation from the membrane and initiates localized proinflammatory …