Distinct repair activities of human 7, 8-dihydro-8-oxoguanine DNA glycosylase and formamidopyrimidine DNA glycosylase for formamidopyrimidine and 7, 8-dihydro-8 …
K Asagoshi, T Yamada, H Terato, Y Ohyama… - Journal of Biological …, 2000 - ASBMB
7, 8-Dihydro-8-oxoguanine (8-oxoG) and 2, 6-diamino-4-hydroxyformamidopyrimidine
(Fapy) are major DNA lesions formed by reactive oxygen species and are involved in
mutagenic and/or lethal events in cells. Both lesions are repaired by human 7, 8-dihydro-8-
oxoguanine DNA glycosylase (hOGG1) and formamidopyrimidine DNA glycosylase (Fpg) in
human andEscherichia coli cells, respectively. In the present study, the repair activities of
hOGG1 and Fpg were compared using defined oligonucleotides containing 8-oxoG and a …
(Fapy) are major DNA lesions formed by reactive oxygen species and are involved in
mutagenic and/or lethal events in cells. Both lesions are repaired by human 7, 8-dihydro-8-
oxoguanine DNA glycosylase (hOGG1) and formamidopyrimidine DNA glycosylase (Fpg) in
human andEscherichia coli cells, respectively. In the present study, the repair activities of
hOGG1 and Fpg were compared using defined oligonucleotides containing 8-oxoG and a …
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