Does an alkaline environment prevent the development of bisphosphonate-related osteonecrosis of the jaw? An experimental study in rats
Objective To investigate the preventive effect of locally applied sodium bicarbonate on
bisphosphonate-related osteonecrosis of the jaw (BRONJ). Study Design Thirty-six Sprague-
Dawley rats were divided into 4 groups. Animals in group I received 0.1 mg/kg sterile saline
3 times per week for 8 weeks. Groups II, III, and IV received intraperitoneal zoledronate
injection in the same manner with the same frequency and duration. The right first molar
tooth was extracted in groups III and IV. One mL 8.4% sodium bicarbonate (SB) was applied …
bisphosphonate-related osteonecrosis of the jaw (BRONJ). Study Design Thirty-six Sprague-
Dawley rats were divided into 4 groups. Animals in group I received 0.1 mg/kg sterile saline
3 times per week for 8 weeks. Groups II, III, and IV received intraperitoneal zoledronate
injection in the same manner with the same frequency and duration. The right first molar
tooth was extracted in groups III and IV. One mL 8.4% sodium bicarbonate (SB) was applied …
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