This article presents a novel method of extending the high-efficiency range of Doherty power amplifiers (DPAs) by utilizing multiple output power back-off (OBO) parameters. The OBO extension techniques of the DPAs, such as complex combining load (CCL), virtual stub (VS), and out-phased current combining (OCC) methods, were defined, and a general expression for these OBO extension techniques was derived. Using the general expression, three OBO extension methods were comparatively and comprehensively analyzed. Based on the analysis, the DPA with an extended OBO can be designed by simultaneously employing multiple back-off techniques with a high degree of freedom. To verify the general expression and its analysis, a DPA design for the frequency band of 3.45–3.75 GHz with GaN HEMTs was conducted using multiple OBO extension techniques of VS and OCC methods for a large OBO of 8.5 dB. Using a long-term evolution (LTE) signal with a signal bandwidth of 20 MHz and a peak-to-average power ratio (PAPR) of 8 dB, the drain efficiency (DE) of 38.9%–56.8% was achieved at the average output power levels of 34.4–36.8 dBm while satisfying ACLR of no larger than −45 dBc with digital predistortion (DPD) linearization. Under excitation of a 5G new radio (NR) signal with a signal bandwidth of 100 MHz and a PAPR of 8 dB, the DE of 38.5%–50.2% was achieved at the average output power levels of 34.6–36.8 dBm with an ACLR of under −24.6 dBc without DPD linearization.