STUDY QUESTION Can transplanted primate testicular cells form seminiferous tubules de
novo, supporting complete spermatogenesis? SUMMARY ANSWER Cryopreserved
testicular cells from a prepubertal monkey can reorganize in an adult monkey recipient testis
forming de novo seminiferous tubular cords supporting complete spermatogenesis. WHAT
IS KNOWN ALREADY De novo morphogenesis of testicular tissue using aggregated cells
from non-primate species grafted either subcutaneously or in the testis can support …

Editorial Comment: Sperm is not just a vessel containing DNA. These exquisite swimmers
also contain molecules around the genome and mitochondrial DNA. Some specially
modified sperm mitochondrial DNA remain during the early stages of embryogenesis, and
since no molecule in the critical process of reproduction is there for no reason, evidence
suggests that embryogenesis partly depends on it. These investigators correlated sperm
mitochondrial DNA copy number and deletion rate in in vitro fertilization to the quality of …