Down-regulation of RORA gene expression in the blood of multiple sclerosis patients
Human antibodies, 2018•content.iospress.com
Multiple sclerosis (MS) is an autoimmune disease characterized by recurrent episodes of
demyelination and loss of oligodendrocytes. The demyelination process is caused by
various subsets of CD4+ T cells with a Th1 and Th17 phenotype. The retinoid acid-related
orphan receptor A (RORA) is expressed in Th17 cells and promote Th17 differentiation. In
this study, we compared the expression level of RORA gene in the blood of 50 relapsing-
remitting MS (RRMS) patients who were treated with IFN-β and 50 healthy controls by …
demyelination and loss of oligodendrocytes. The demyelination process is caused by
various subsets of CD4+ T cells with a Th1 and Th17 phenotype. The retinoid acid-related
orphan receptor A (RORA) is expressed in Th17 cells and promote Th17 differentiation. In
this study, we compared the expression level of RORA gene in the blood of 50 relapsing-
remitting MS (RRMS) patients who were treated with IFN-β and 50 healthy controls by …
Abstract
Multiple sclerosis (MS) is an autoimmune disease characterized by recurrent episodes of demyelination and loss of oligodendrocytes. The demyelination process is caused by various subsets of CD4+ T cells with a Th1 and Th17 phenotype. The retinoid acid-related orphan receptor A (RORA) is expressed in Th17 cells and promote Th17 differentiation. In this study, we compared the expression level of RORA gene in the blood of 50 relapsing-remitting MS (RRMS) patients who were treated with IFN-β and 50 healthy controls by TaqMan Quantitative Real-Time PCR.
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