Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats: the effects of vitamin E and catechin

Y Kalender, M Yel, S Kalender - Toxicology, 2005 - Elsevier
Doxorubicin (DXR) is an anthracycline antibiotic, broady used in tumor therapy. In the
present study we investigated whether vitamin E and catechin can reduce the toxic effects of
doxorubicin. Vitamin E (200IU/kg/week), catechin (200mg/kg/week), doxorubicin
(5mg/kg/week), doxorubicin+ vitamin E (200IU/kg/week), doxorubicin+ catechin
(200mg/kg/week) combinations were given to rats weighing 210–230g (n= 6/group).
Changes in major enzymes participating in free radical metabolism superoxide dismutase …
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