Drivers of the Warburg phenotype
RA Cairns - The Cancer Journal, 2015 - journals.lww.com
… that contribute to the Warburg phenotype. The hypoxia-inducible factor (HIF) signaling
pathway is perhaps the best example of a driver of the Warburg phenotype that responds to both …
pathway is perhaps the best example of a driver of the Warburg phenotype that responds to both …
The harsh microenvironment in early breast cancer selects for a Warburg phenotype
… to emerge from DCIS selection is the Warburg Effect (WE) phenotype, which is defined as …
known driver gene mutations. This suggests that there may be mutation-independent drivers of …
known driver gene mutations. This suggests that there may be mutation-independent drivers of …
How the Warburg effect supports aggressiveness and drug resistance of cancer cells?
P Icard, S Shulman, D Farhat, JM Steyaert… - Drug Resistance …, 2018 - Elsevier
… The Warburg effect also favors an intracellular alkaline pH which is a driving force in many
… with the occurrence of multiple new cell phenotypes which enhance cancer cell growth and …
… with the occurrence of multiple new cell phenotypes which enhance cancer cell growth and …
Revisiting the Warburg effect: historical dogma versus current understanding
P Vaupel, G Multhoff - The Journal of physiology, 2021 - Wiley Online Library
… Warburg effect, ie aerobic glycolysis in the presence of oxygen and – in principle – functioning
mitochondria, constitutes a major driver … The Warburg phenotype constitutes a metabolic …
mitochondria, constitutes a major driver … The Warburg phenotype constitutes a metabolic …
The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression
P Vaupel, H Schmidberger, A Mayer - International journal of …, 2019 - Taylor & Francis
… and consequences of the Warburg effect were described only … metabolic feature of the
Warburg phenotype, is caused by … (c) accumulation of lactate which drives tumor progression and …
Warburg phenotype, is caused by … (c) accumulation of lactate which drives tumor progression and …
Pathogens hijack host cell metabolism: intracellular infection as a driver of the Warburg effect in cancer and other chronic inflammatory conditions
AD Proal, MB VanElzakker - Immunometabolism, 2021 - journals.lww.com
… In order to activate and respond to the infection, the cells would additionally adapt a Warburg
phenotype, since a Warburg metabolism drives the essential increase in ATP production …
phenotype, since a Warburg metabolism drives the essential increase in ATP production …
Lactate and lactate transporters as key players in the maintenance of the Warburg effect
… The Warburg metabolic phenotype proved to be a useful tool not only for clinical detection
of glucose-addicted tumours, but also to monitor tumour growth and dissemination by 18 F-…
of glucose-addicted tumours, but also to monitor tumour growth and dissemination by 18 F-…
[HTML][HTML] Warburg effect metabolism drives neoplasia in a Drosophila genetic model of epithelial cancer
T Eichenlaub, R Villadsen, FCP Freitas, D Andrejeva… - Current Biology, 2018 - cell.com
… ), a key enzyme in Warburg effect metabolism, as a cooperating … LDHA expression promotes
a transformed phenotype in a human … role in driving neoplasia than previously appreciated. …
a transformed phenotype in a human … role in driving neoplasia than previously appreciated. …
The Warburg effect and drug resistance
B Bhattacharya, MF Mohd Omar… - British journal of …, 2016 - Wiley Online Library
The Warburg effect describes the increased utilization of … More recently, studies have begun
to reveal how the Warburg effect … for utilizing the Warburg effect in future drug development. …
to reveal how the Warburg effect … for utilizing the Warburg effect in future drug development. …
Warburg and Krebs and related effects in cancer
JE Unterlass, NJ Curtin - Expert Reviews in Molecular Medicine, 2019 - cambridge.org
… of the drivers and consequences of the Warburg effect in … Here we discuss the initial findings
of Warburg and coworkers … shown to contribute to the Warburg phenotype in cancer, such as …
of Warburg and coworkers … shown to contribute to the Warburg phenotype in cancer, such as …