Drug–drug salt forms of ciprofloxacin with diflunisal and indoprofen
CrystEngComm, 2014•pubs.rsc.org
Two salt forms of a fluoroquinolone antibacterial drug, ciprofloxacin (CIP), with non-steroidal
anti-inflammatory drugs, diflunisal (CIP/DIF) and indoprofen (CIP/INDP/H2O), were
synthesized and characterized by PXRD, FTIR, DSC, TGA and HSM. Crystal structure
determination allowed us to study the drug–drug interactions and the piperazine-based
synthon (protonated piperazinecarboxylate) in the two forms, which is potentially useful for
the crystal engineering of new salt forms of many piperazine-based drugs.
anti-inflammatory drugs, diflunisal (CIP/DIF) and indoprofen (CIP/INDP/H2O), were
synthesized and characterized by PXRD, FTIR, DSC, TGA and HSM. Crystal structure
determination allowed us to study the drug–drug interactions and the piperazine-based
synthon (protonated piperazinecarboxylate) in the two forms, which is potentially useful for
the crystal engineering of new salt forms of many piperazine-based drugs.
Two salt forms of a fluoroquinolone antibacterial drug, ciprofloxacin (CIP), with non-steroidal anti-inflammatory drugs, diflunisal (CIP/DIF) and indoprofen (CIP/INDP/H2O), were synthesized and characterized by PXRD, FTIR, DSC, TGA and HSM. Crystal structure determination allowed us to study the drug–drug interactions and the piperazine-based synthon (protonated piperazinecarboxylate) in the two forms, which is potentially useful for the crystal engineering of new salt forms of many piperazine-based drugs.
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