Drug loaded implantable devices to treat cardiovascular disease
M Adhami, NK Martin, C Maguire… - Expert Opinion on …, 2023 - Taylor & Francis
Expert Opinion on Drug Delivery, 2023•Taylor & Francis
Introduction It is widely acknowledged that cardiovascular diseases (CVDs) continue to be
the leading cause of death globally. Furthermore, CVDs are the leading cause of diminished
quality of life for patients, frequently as a result of their progressive deterioration. Medical
implants that release drugs into the body are active implants that do more than just provide
mechanical support; they also have a therapeutic role. Primarily, this is achieved through the
controlled release of active pharmaceutical ingredients (API) at the implementation site …
the leading cause of death globally. Furthermore, CVDs are the leading cause of diminished
quality of life for patients, frequently as a result of their progressive deterioration. Medical
implants that release drugs into the body are active implants that do more than just provide
mechanical support; they also have a therapeutic role. Primarily, this is achieved through the
controlled release of active pharmaceutical ingredients (API) at the implementation site …
Introduction
It is widely acknowledged that cardiovascular diseases (CVDs) continue to be the leading cause of death globally. Furthermore, CVDs are the leading cause of diminished quality of life for patients, frequently as a result of their progressive deterioration. Medical implants that release drugs into the body are active implants that do more than just provide mechanical support; they also have a therapeutic role. Primarily, this is achieved through the controlled release of active pharmaceutical ingredients (API) at the implementation site.
Areas covered
In this review, the authors discuss drug-eluting stents, drug-eluting vascular grafts, and drug-eluting cardiac patches with the aim of providing a broad overview of the three most common types of cardiac implant.
Expert opinion
Drug eluting implants are an ideal alternative to traditional drug delivery because they allow for accurate drug release, local drug delivery to the target tissue, and minimize the adverse side effects associated with systemic administration. Despite the fact that there are still challenges that need to be addressed, the ever-evolving new technologies are making the fabrication of drug-eluting implants a rewarding therapeutic endeavor with the possibility for even greater advances.
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