Dual role of nitric oxide in Alzheimer's Disease

A Azargoonjahromi - Nitric Oxide, 2023 - Elsevier
Nitric oxide (NO), an enzymatic product of nitric oxide synthase (NOS), has been associated
with a variety of neurological diseases such as Alzheimer's disease (AD). NO has long been
thought to contribute to neurotoxic insults caused by neuroinflammation in AD. This
perception shifts as more attention is paid to the early stages before cognitive problems
manifest. However, it has revealed a compensatory neuroprotective role for NO that protects
synapses by increasing neuronal excitability. NO can positively affect neurons by inducing …
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