Background Unexpected allergic reactions to peanut are the most common cause of fatal
food-related anaphylaxis. Mechanisms underlying the variable severity of peanut-allergic
reactions remain unclear. Objectives We sought to expand mechanistic understanding of
reaction severity in peanut allergy. Methods We performed an integrated transcriptomic and
epigenomic study of peanut-allergic children as they reacted in vivo during double-blind,
placebo-controlled peanut challenges. We integrated whole-blood transcriptome and CD4+ …