Dual-targeting nanosystem for enhancing photodynamic therapy efficiency
Photodynamic therapy (PDT) has been recognized as a valuable treatment option for
localized cancers. Herein, we demonstrate a cellular and subcellular targeted strategy to
facilitate PDT efficacy. The PDT system was fabricated by incorporating a cationic porphyrin
derivative (MitoTPP) onto the polyethylene glycol (PEG)-functionalized and folic acid-
modified nanographene oxide (NGO). For this PDT system, NGO serves as the carrier for
MitoTPP as well as the quencher for MitoTPP's fluorescence and singlet oxygen (1O2) …
localized cancers. Herein, we demonstrate a cellular and subcellular targeted strategy to
facilitate PDT efficacy. The PDT system was fabricated by incorporating a cationic porphyrin
derivative (MitoTPP) onto the polyethylene glycol (PEG)-functionalized and folic acid-
modified nanographene oxide (NGO). For this PDT system, NGO serves as the carrier for
MitoTPP as well as the quencher for MitoTPP's fluorescence and singlet oxygen (1O2) …
[引用][C] Dual-Targeting Nanosystem for Enhancing Photodynamic Therapy Efficiency
X Jiangsheng, Z Fang, W Hao, Y Changmin… - 2015
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