Objectives: Multimodal analgesia is widely advocated for the control of perioperative pain in
an effort to reduce the use of opioid. Duloxetine is a selective inhibitor of serotonin and
norepinephrine reuptake with efficacy for chronic pain conditions. The primary objective of
this study was to evaluate the efficacy of two 60 mg oral doses of duloxetine in terms of
fentanyl consumption during the postoperative period in patients undergoing elective spine
surgery. Materials and Methods: This study was prospective, double-blind, randomized, and …