… Dynorphin is the putative endogenous ligand for the kappa opiate receptor [2, 5, 26]. For
these reasons it has been suggested that dynorphin and the kappa opiate receptor may play a …

… These results support the role of the κ opioid system in stress responses through an
interaction with the CRF system. Whether CRF drives dynorphin and/or dynorphin drives CRF …

… dynorphin levels in areas of the brain, and that acute sporadic use would not increase dynorphin
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… Dynorphins (DYNs) are neuropeptides with widespread distribution and diverse functions in
the … Thus, interneurons contribute to cortical information processing via complex interactions …

… the recently defined neurobehavioral interactions between CRF and dynorphin, and discuss
… is a key step in understanding potential sites of dynorphin action, and allows for discrete cell …

… site provided the basis for a widely accepted working definition of the K receptor: a non-Ix,
non-~ binding site which exhibits high affinity for the dynorphin … concentrations of dynorphin, …

… C57BL/6 and the DBA/2 mice Male N/A Strain/site-related differences … sites and dynorphin
A 1-13 in the amygdala and DYN A 1-8 in the VTA. DBA/2 mice had more KOR binding sites, …

… binding selectivity using chimeric receptor and site-directed mutagenesis approaches. In …
has provided insight for ligand–receptor interactions allowing new concepts for novel drug …

… peptide that incorporates dynorphin A and dynorphin B was called dynorphin (1–32) or big
… -opioid receptor and binding sites for the dynorphin-like peptides. Immunohistochemical and …

… However, its antinociceptive function 'in vivo' was difficult to assess possibly due to its lack
of selectivity for the x opioid receptor ' but also to its interaction with non-opioid binding sites …