[HTML][HTML] Dysfunctional stem and progenitor cells impair fracture healing with age
Successful fracture healing requires the simultaneous regeneration of both the bone and
vasculature; mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while
endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the
fracture site. In the elderly, the healing process is slowed, partly due to decreased
regenerative function of these stem and progenitor cells. MSCs from older individuals are
impaired with regard to cell number, proliferative capacity, ability to migrate, and …
vasculature; mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while
endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the
fracture site. In the elderly, the healing process is slowed, partly due to decreased
regenerative function of these stem and progenitor cells. MSCs from older individuals are
impaired with regard to cell number, proliferative capacity, ability to migrate, and …
Dysfunctional Stem and Progenitor Cells Impair Fracture Healing with Age
Successful fracture healing requires the simultaneous regeneration of both the bone and
vasculature; mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while
endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the
fracture site. In the elderly, the healing process is slowed, partly due to decreased
regenerative function of these stem and progenitor cells. MSCs from older individuals are
impaired with regard to cell number, proliferative capacity, ability to migrate, and …
vasculature; mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while
endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the
fracture site. In the elderly, the healing process is slowed, partly due to decreased
regenerative function of these stem and progenitor cells. MSCs from older individuals are
impaired with regard to cell number, proliferative capacity, ability to migrate, and …
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