ERK5 and ERK2 cooperate to regulate NF-κB and cell transformation
We have previously demonstrated an involvement of MEK5 and ERK5 in RafBXB-stimulated
focus formation in NIH3T3 cells. We find here that MEK5 and ERK5 cooperate with the
RafBXB effectors MEK1/2 and ERK1/2 to induce foci. To further understand MEK5-ERK5-
dependent signaling, we examined potential MEK5-ERK5 effectors that might influence
focus-forming activity. Consistent with results from our focus-formation assays, constitutively
active variants of MEK5 and MEK1 synergize to activate NF-κB, and MEK5 and ERK5 are …
focus formation in NIH3T3 cells. We find here that MEK5 and ERK5 cooperate with the
RafBXB effectors MEK1/2 and ERK1/2 to induce foci. To further understand MEK5-ERK5-
dependent signaling, we examined potential MEK5-ERK5 effectors that might influence
focus-forming activity. Consistent with results from our focus-formation assays, constitutively
active variants of MEK5 and MEK1 synergize to activate NF-κB, and MEK5 and ERK5 are …
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