Early-onset ankylosing spondylitis is associated with a functional MICA polymorphism
H Amroun, H Djoudi, M Busson, R Allat… - Human immunology, 2005 - Elsevier
Major histocompatibility complex (MHC) class I chain–related A (MICA) molecules deliver
activating signals through the NKG2D receptor expressed on the surface of natural killer
(NK), CD8αβ and γδ T cells, and the MICA gene is polymorphic. The recently described
MICA amino acid substitution at position 129 (MICA-129) seems to affect its binding to
NKG2D. We investigated whether this dimorphism (MICA-129met [methionine] and MICA-
129val [valine]) is associated with susceptibility to ankylosing spondylitis (AS) in a cohort of …
activating signals through the NKG2D receptor expressed on the surface of natural killer
(NK), CD8αβ and γδ T cells, and the MICA gene is polymorphic. The recently described
MICA amino acid substitution at position 129 (MICA-129) seems to affect its binding to
NKG2D. We investigated whether this dimorphism (MICA-129met [methionine] and MICA-
129val [valine]) is associated with susceptibility to ankylosing spondylitis (AS) in a cohort of …
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