[HTML][HTML] Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins are not regulated through oligomerization
M Vooijs, EH Schroeter, Y Pan, M Blandford… - Journal of Biological …, 2004 - ASBMB
Intramembrane cleaving proteases such as site 2 protease, γ-secretase, and signal peptide
peptidase hydrolyze peptide bonds within the transmembrane domain (TMD) of signaling
molecules such as SREBP, Notch, and HLA-E, respectively. All three enzymes require a
prior cleavage at the juxtamembrane region by another protease. It has been proposed that
removing the extracellular domain allows dissociation of substrate TMD, held together by the
extracellular domain or loop. Using γ-secretase as a model intramembrane cleaving …
peptidase hydrolyze peptide bonds within the transmembrane domain (TMD) of signaling
molecules such as SREBP, Notch, and HLA-E, respectively. All three enzymes require a
prior cleavage at the juxtamembrane region by another protease. It has been proposed that
removing the extracellular domain allows dissociation of substrate TMD, held together by the
extracellular domain or loop. Using γ-secretase as a model intramembrane cleaving …
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