Ectromelia virus infections of mice as a model to support the licensure of anti-orthopoxvirus therapeutics
S Parker, AM Siddiqui, G Painter, J Schriewer… - Viruses, 2010 - mdpi.com
The absence of herd immunity to orthopoxviruses and the concern that variola or
monkeypox viruses could be used for bioterroristic activities has stimulated the development
of therapeutics and safer prophylactics. One major limitation in this process is the lack of
accessible human orthopoxvirus infections for clinical efficacy trials; however, drug licensure
can be based on orthopoxvirus animal challenge models as described in the “Animal
Efficacy Rule”. One such challenge model uses ectromelia virus, an orthopoxvirus, whose …
monkeypox viruses could be used for bioterroristic activities has stimulated the development
of therapeutics and safer prophylactics. One major limitation in this process is the lack of
accessible human orthopoxvirus infections for clinical efficacy trials; however, drug licensure
can be based on orthopoxvirus animal challenge models as described in the “Animal
Efficacy Rule”. One such challenge model uses ectromelia virus, an orthopoxvirus, whose …
Ectromelia Virus Infections of Mice as a Model to Support the Licensure of Anti-Orthopoxvirus Therapeutics
RM Buller, J Schriewer, G Painter, AM Siddiqui… - 2010 - agris.fao.org
The absence of herd immunity to orthopoxviruses and the concern that variola or
monkeypox viruses could be used for bioterroristic activities has stimulated the development
of therapeutics and safer prophylactics. One major limitation in this process is the lack of
accessible human orthopoxvirus infections for clinical efficacy trials; however, drug licensure
can be based on orthopoxvirus animal challenge models as described in the “Animal
Efficacy Rule”. One such challenge model uses ectromelia virus, an orthopoxvirus, whose …
monkeypox viruses could be used for bioterroristic activities has stimulated the development
of therapeutics and safer prophylactics. One major limitation in this process is the lack of
accessible human orthopoxvirus infections for clinical efficacy trials; however, drug licensure
can be based on orthopoxvirus animal challenge models as described in the “Animal
Efficacy Rule”. One such challenge model uses ectromelia virus, an orthopoxvirus, whose …
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