Effect of a chikungunya virus–like particle vaccine on safety and tolerability outcomes: a randomized clinical trial
GL Chen, EE Coates, SH Plummer, CA Carter… - Jama, 2020 - jamanetwork.com
Importance Chikungunya virus (CHIKV) is a mosquito-borneAlphavirusprevalent worldwide.
There are currently no licensed vaccines or therapies. Objective To evaluate the safety and
tolerability of an investigational CHIKV virus–like particle (VLP) vaccine in endemic regions.
Design, Setting, and Participants This was a randomized, placebo-controlled, double-blind,
phase 2 clinical trial to assess the vaccine VRC-CHKVLP059-00-VP (CHIKV VLP). The trial
was conducted at 6 outpatient clinical research sites located in Haiti, Dominican Republic …
There are currently no licensed vaccines or therapies. Objective To evaluate the safety and
tolerability of an investigational CHIKV virus–like particle (VLP) vaccine in endemic regions.
Design, Setting, and Participants This was a randomized, placebo-controlled, double-blind,
phase 2 clinical trial to assess the vaccine VRC-CHKVLP059-00-VP (CHIKV VLP). The trial
was conducted at 6 outpatient clinical research sites located in Haiti, Dominican Republic …
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