Effect of bromine substitution on human dermal absorption of polybrominated diphenyl ethers
Human dermal absorption of eight mono-to deca-brominated diphenyl ethers (PBDEs) was
investigated for the first time using EPISKIN human skin equivalent tissue. Using a standard
in vitro protocol, EPISKIN tissues mounted in specially designed diffusion cells were
exposed to the target PBDEs for 24 h. Estimated steady-state flux (J ss) and permeation
coefficients (P app) across the skin increased with decreasing bromine substitution from
BDE-153 (P app= 4.0× 10–4 cm/h) to BDE-1 (P app= 1.1× 10–2 cm/h). This was …
investigated for the first time using EPISKIN human skin equivalent tissue. Using a standard
in vitro protocol, EPISKIN tissues mounted in specially designed diffusion cells were
exposed to the target PBDEs for 24 h. Estimated steady-state flux (J ss) and permeation
coefficients (P app) across the skin increased with decreasing bromine substitution from
BDE-153 (P app= 4.0× 10–4 cm/h) to BDE-1 (P app= 1.1× 10–2 cm/h). This was …
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