The effect of gellan gum on the gelation behavior and in-vitro release of a specific drug
named pilocarpine hydrochloride from different ophthalmic formulations based on
poloxamer 407 is examined. The mixture of 0.3 wt% gellan gum and 18 wt% poloxamer
(PM) solutions show a considerable increase in gel strength in physiological condition. Gel
dissolution rate from PM based formulation is significantly decreased due to the addition of
gellan gum. FTIR spectra analysis witnesses an interaction in between single bondOH …

The effect of gellan gum on the gelation behavior and in-vitro release of a specific drug
named pilocarpine hydrochloride from different ophthalmic formulations based on
poloxamer 407 is examined. The mixture of 0.3 wt% gellan gum and 18 wt% poloxamer
(PM) solutions show a considerable increase in gel strength in physiological condition. Gel
dissolution rate from PM based formulation is significantly decreased due to the addition of
gellan gum. FTIR spectra analysis witnesses an interaction in between–OH groups of two …