Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system

G Chevalier, E Siopi, L Guenin-Macé, M Pascal… - Nature …, 2020 - nature.com
… in these depressive-like behaviors, we compared the effects of rimonabant to the effects
of … In contrast to rimonabant, AM6545 did not reverse the antidepressant effect of JZL184 (Fig. …

The impact of gut microbiota on depressive-like behaviors and adult hippocampal neurogenesis requires the endocannabinoid system

G Chevalier, E Siopi, L Guenin-Macé, M Pascal… - bioRxiv, 2019 - biorxiv.org
… It has been reported that nutritional n-3 PUFA deficiency abolishes eCB-mediated neuronal
depressive-like behaviors in mice 102, 103 . We may speculate that UCMS microbiota

Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice

F Guida, F Turco, M Iannotta, D De Gregorio… - Brain, behavior, and …, 2018 - Elsevier
… The endocannabinoid system has been shown to be … the alteration of intestinal flora affected
mouse behaviour, we … -induced microbiota perturbation leads to a depressive-like behaviour

Cannabidiol antidepressant-like effect in the lipopolysaccharide model in mice: Modulation of inflammatory pathways

E Florensa-Zanuy, E Garro-Martínez, A Adell… - Biochemical …, 2021 - Elsevier
… NF-κB is a transcription factor that mediates the inflammatory response. Under basal … can
infer that the sickness behavior is not interfering with the depressive-like behavior at this time-…

[HTML][HTML] Gut bacteria, endocannabinoid system, and marijuana addiction: Novel therapeutic implications

KK Pinapati, S Vidya, MF Khan, D Mandal… - Health Sciences …, 2024 - Elsevier
… of gut bacteria in ECS and marijuana-mediated neuromodulation … The alterations in the
intestinal flora can affect many areas of … results in depressive like symptoms and gut inflammation …

The endocannabinoidome as a substrate for noneuphoric phytocannabinoid action and gut microbiome dysfunction in neuropsychiatric disorders

V Di Marzo - Dialogues in clinical neuroscience, 2020 - Taylor & Francis
… than cannabinoid receptor type 1 (CB 1 ) and cannabinoid … , mediate the negative or
beneficial effects on the “leaky gut,” … depressive-like behaviorNat Med201925233734930643290 …

The microbiome and gut endocannabinoid system in the regulation of stress responses and metabolism

RK Srivastava, B Lutz, I Ruiz de Azua - Frontiers in cellular …, 2022 - frontiersin.org
… in the gut microbiome affect our mental and metabolic health. … In addition to neuronal effects
mediated by the gut-brain axis, … in decreasing depressive-like behavior in stressed rats but …

The gut microbiome–endocannabinoidome axis: a new way of controlling metabolism, inflammation, and behavior

C Silvestri, V Di Marzo - Function, 2023 - academic.oup.com
… with the two endogenous ligands of cannabinoid type-1 and type… proteins controlling their
levels or mediating their actions. Along … The adverse effects of the transferred microbiota were …

Endocannabinoid system mediates the association between gut-microbial diversity and anhedonia/amotivation in a general population cohort

A Minichino, MA Jackson, M Francesconi… - Molecular …, 2021 - nature.com
… /amotivation and suggest the gut microbiota-endocannabinoid axis as a promising therapeutic
… animal study that showed that the endocannabinoid system mediates the effect of the gut-…

Gut microbiota-based metabolites of Xiaoyao Pills (a typical Traditional Chinese medicine) ameliorate depression by inhibiting fatty acid amide hydrolase levels in …

ZW Zhang, P Han, J Fu, H Yu, H Xu, JC Hu… - Journal of …, 2023 - Elsevier
… interact with gut microbiota after oral administration, which could affect the therapeutic effect
of … , including endocannabinoid anandamide and sleep-inducing oleamide, thus terminating …